The Carone lab investigates repetitive elements in the human genome and the implications of misregulation of repetitive elements in disease.  We use molecular cytology and biochemical tools to examine the expression of repetitive sequences within their nuclear environment in order to identify and investigate their interacting partners at the chromatin and protein level.  Current projects in the lab aim to understand both the cause and consequence of locus-specific expression of HSATII, a pericentric tandemly repeated satellite sequence, in cancer cells.   We are also interested in the evolution of pericentric tandem repeats in the primate lineage and contributing to the assembly of pericentric satellite sequences in the human genome.